The team that have not won a home match since October 12th take on a team with only one league win away from home, back on September 14th tomorrow night with both sides on the same amount of points in League Two.
Ben Chorley could make his debut for Pompey now that he has completed his three match ban but Jed Wallace is doubtful after coming off at Morecambe with a knock. Simon Ferry and Ricky Holmes are still on the treatment table whilst David Connolly is set to miss out again having not trained all week.
Former Pompey youngster Paris Cowan-Hall will miss the match because of a medial ligament injury and Jon-Paul Pitman is also out. Charles Dunne and Tommy Fletcher are long term injuries but on-loan Forest Green striker Reece Styche is hoping to keep his place in the side.
After the frustration of conceding such a soft goal late on at Morecambe, Richie Barker really needs a win before Saturday's crunch game against Torquay and the Chairboys may be the ideal opposition.
Wycombe looked like a good team when they stole a late 2-2 draw at Fratton Park in the rearranged fixture earlier in the season but have only won once (a 4-1 victory at bottom side Northampton) since that night and confidence is low after they squandered a two goal lead at Mansfield to draw the game.
Their run draws parallels with Portsmouth's and with both sides stuck on 29 points, tomorrow's match is a huge opportunity to end such an abysmal run of form with a confidence boosting win.
Barker's main decision ahead of the match will be whether he decides to throw centre back Chorley straight into the team and at whose expense? Joe Devera would be the likely candidate to make way but he has been playing well since the turn of the year and it could be argued that Sonny Bradley should be dropped instead.
Bradley is a prospect but has been rather inconsistent and could well be seen as "too nice" when a centre back who takes no prisoners is the type of player needed for a run of games like this where defeat could really damage Pompey's future prospects as a Football League club.
If Wallace misses the match then it's time that Andy Barcham stepped up. It has been too long since he made a meaningful contribution to a match and we all know that he can be brilliant on his day, but those days don't come often enough.
Thankfully Pompey seem to have a trump card in Jake Jervis who looks he part up front and in strike partner Ryan Taylor he has good foil beside him to do some damage. It's likely that the visitors will score tomorrow but it's keeping them out at the other end which will be the issue so hopefully Chorley can make a difference if he plays.
The importance of this match at Adams Park cannot be understated. If there is to be a loser then that puts huge pressure on that team for their matches on Saturday which will have a massive impact on the relegation battle.
So, please don't lose this one, Pompey!
Predicted Starting Line-Ups
GK: Matt INGRAM
RB: Marvin McCOY
CB: Gary DOHERTY
CB: Leon JOHNSON
LB: Jordan MUSTOE
RM: Anthony JEFFREY
CM: Stuart LEWIS
CM: Josh SCOWEN
LM: Sam WOOD
CF: Matt McCLURE
CF: Reece STYCHE
GK: Trevor CARSON
RB: Daniel ALFEI
CB: Sonny BRADLEY
CB: Ben CHORLEY
LB: Marcos PAINTER
RM: Wes FOGDEN
CM: Nicky SHOREY
CM: Thery RACON
LM: Andy BARCHAM
CF: Ryan TAYLOR
CF: Jake JERVIS
With both teams on such a poor run and with hoodoos to banish it makes perfect sense for this to be a draw.
Wycombe Wanderers 1 Portsmouth 1