Having got the season off to an excellent start with two fantastic results at Fratton Park, Pompey will now look to do the business away from home and prove that they are the real deal this season.
Paul Cook has a selection dilemma on his hands after his so-called "squad players" performed excellently in the win against Derby on Wednesday. Brian Murphy should take his place back in goal but Jayden Stockley may well start tomorrow's match ahead of Matt Tubbs.
Former Pompey striker Jake Jervis is likely to miss out on facing his previous club after sustaining an injury during Argyle's 2-1 defeat to Gillingham on Tuesday. Midfielder Craig Tanner could start after scoring during that game whilst striker Josh Simpson may also be handed a start after being on the bench for Plymouth's first two matches.
Paul Cook has vowed to play the same way away from home as his team has at Fratton Park so far this season but Plymouth will offer a much sterner test than Dagenham last week having also won their opening day fixture 2-0 at Wimbledon, even if they succumbed to a late defeat against Gillingham.
Argyle are much like Pompey in a way as they are also one of the pre-season favourites and have a highly rated new manager in charge in Derek Adams who has had much success in Scotland. He also likes his team to play a 4-2-3-1 formation with the dangerous Reuben Reid up top.
Craig Tanner is also one to watch for the home side as is Josh Simpson who could make an impact from the bench if things aren't going Argyle's way.
However, under the Cook regime there should be no reason to fear Plymouth after Wednesday's win over Derby proved that Pompey can take on Championship sides and it's not just the first-choice eleven that have quality with many staking a claim for a starting berth tomorrow.
In truth, it's likely that Jones will be dropped for Murphy after his misjudgement for Derby's equaliser and Stockley's "man of the match" performance may see him picked over Tubbs who looked a little lost last Saturday. Otherwise, expect the same starting eleven that beat Dagenham to begin tomorrow's match with Gary Roberts pulling the strings in midfield.
Still, it's impossible to know how this side will perform away from Fratton Park and all Pompey fans will know just how dreadful Portsmouth have been on the road since the FA Cup winning season of 2007/2008 and so that has to change.
Cook's 4-2-3-1 system should be set perfectly for an away performance and it's good that the team travelled to Devon early to get settled so they can have no excuses if they lose tomorrow.
But this team has given fans a new belief that they can take anyone on and be positive which is something that has been lacking from previous Pompey teams. Whether that will be enough to take three points from Home Park tomorrow, who knows?
Predicted Starting Line-Ups
GK: Luke McCORMICK
RB: Kelvin MELLOR
CB: Curtis NELSON
CB: Peter HARTLEY
LB: Gary SAWYER
DM: Carl McHUGH
DM: Hiram BOATENG
RM: Craig TANNER
AM: Graham CAREY
LM: Gregg WYLDE
CF: Reuben REID
GK: Brian MURPHY
RB: Ben DAVIES
CB: Christian BURGESS
CB: Matt CLARKE
LB: Enda STEVENS
DM: Michael DOYLE
DM: Nigel ATANGANA
RM: Gareth EVANS
AM: Gary ROBERTS
LM: Kyle BENNETT
CF: Jayden STOCKLEY
Last Time: Plymouth Argyle 3 Portsmouth 0 (League Two - 15/11/2014)
Reuben Reid converted an early penalty after Nicky Shorey had fouled Lewis Allessandra in the box and then the latter got on the scoresheet himself soon after with a simple goal having made a mockery of Ben Chorley.
Reid bagged his second of the game with a similar goal to end the match as a contest after just 29 minutes. Argyle could have had more in what was a truly embarrassing defeat for Andy Awford's men.
I'm looking forward to an away game for the first time in ages as it should be an entertaining affair between (potentially) two of the best teams in the division. A draw wouldn't be a bad result so early in the season.
Plymouth Argyle 1 Portsmouth 1